Molecular biology and pathology of lymphangiogenesis.
Identifieur interne : 006A19 ( Main/Exploration ); précédent : 006A18; suivant : 006A20Molecular biology and pathology of lymphangiogenesis.
Auteurs : Terhi Karpanen [Finlande] ; Kari Alitalo [Finlande]Source :
- Annual review of pathology [ 1553-4006 ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Biologie moléculaire (), Endothélium lymphatique (cytologie), Endothélium lymphatique (métabolisme), Facteurs de croissance endothéliale vasculaire (génétique), Facteurs de croissance endothéliale vasculaire (métabolisme), Humains, Lymphangiogenèse (génétique), Lymphoedème (anatomopathologie), Lymphoedème (génétique), Lymphoedème (métabolisme), Marqueurs biologiques (métabolisme), Modèles animaux, Régulation de l'expression des gènes au cours du développement, Souris, Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- anatomopathologie : Lymphoedème, Vaisseaux lymphatiques.
- cytologie : Endothélium lymphatique.
- génétique : Facteurs de croissance endothéliale vasculaire, Lymphangiogenèse, Lymphoedème.
- métabolisme : Endothélium lymphatique, Facteurs de croissance endothéliale vasculaire, Lymphoedème, Marqueurs biologiques, Vaisseaux lymphatiques.
- Animaux, Biologie moléculaire, Humains, Modèles animaux, Régulation de l'expression des gènes au cours du développement, Souris.
English descriptors
- KwdEn :
- Animals, Biomarkers (metabolism), Endothelium, Lymphatic (cytology), Endothelium, Lymphatic (metabolism), Gene Expression Regulation, Developmental, Humans, Lymphangiogenesis (genetics), Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphedema (genetics), Lymphedema (metabolism), Lymphedema (pathology), Mice, Models, Animal, Molecular Biology (methods), Vascular Endothelial Growth Factors (genetics), Vascular Endothelial Growth Factors (metabolism).
- MESH :
- chemical , genetics : Vascular Endothelial Growth Factors.
- chemical , metabolism : Biomarkers, Vascular Endothelial Growth Factors.
- cytology : Endothelium, Lymphatic.
- genetics : Lymphangiogenesis, Lymphedema.
- metabolism : Endothelium, Lymphatic, Lymphatic Vessels, Lymphedema.
- methods : Molecular Biology.
- pathology : Lymphatic Vessels, Lymphedema.
- Animals, Gene Expression Regulation, Developmental, Humans, Mice, Models, Animal.
Abstract
The lymphatic vasculature is essential for the maintenance of tissue fluid balance, immune surveillance, and adsorption fatty acids in the gut. The lymphatic vessels are also crucially involved in the pathogenesis of diseases such as tumor metastasis, lymphedema, and various inflammatory conditions. Attempts to control or treat these diseases have drawn a lot of interest to lymphatic vascular research during the past few years. Recently, several markers specific for lymphatic endothelium and models for lymphatic vascular research have been characterized, enabling great technical progress in lymphatic vascular biology, and many critical regulators of lymphatic vessel growth have been identified. Despite these significant achievements, our understanding of the lymphatic vessel development and pathogenesis is still rather limited. Several key questions remain to be resolved, including the relative contributions of different pathways targeting lymphatic vasculature, the molecular and cellular processes of lymphatic maturation, and the detailed mechanisms of tumor metastasis via the lymphatic system.
DOI: 10.1146/annurev.pathmechdis.3.121806.151515
PubMed: 18039141
Affiliations:
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lymphatique</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelium, Lymphatic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lymphangiogenesis</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteurs de croissance endothéliale vasculaire</term><term>Lymphangiogenèse</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Biology</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Endothélium lymphatique</term><term>Facteurs de croissance endothéliale vasculaire</term><term>Lymphoedème</term><term>Marqueurs biologiques</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term><term>Lymphedema</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Gene Expression Regulation, Developmental</term><term>Humans</term><term>Mice</term><term>Models, Animal</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Biologie moléculaire</term><term>Humains</term><term>Modèles animaux</term><term>Régulation de l'expression des gènes au cours du développement</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic vasculature is essential for the maintenance of tissue fluid balance, immune surveillance, and adsorption fatty acids in the gut. 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Several key questions remain to be resolved, including the relative contributions of different pathways targeting lymphatic vasculature, the molecular and cellular processes of lymphatic maturation, and the detailed mechanisms of tumor metastasis via the lymphatic system.</div></front></TEI><affiliations><list><country><li>Finlande</li></country><region><li>Uusimaa</li></region><settlement><li>Helsinki</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="Finlande"><noRegion><name sortKey="Karpanen, Terhi" sort="Karpanen, Terhi" uniqKey="Karpanen T" first="Terhi" last="Karpanen">Terhi Karpanen</name></noRegion><name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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